MXD3 Antibody, FITC conjugated

Code CSB-PA015252LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MXD3 Polyclonal antibody
Uniprot No.
Target Names
MXD3
Alternative Names
bHLHc13 antibody; Class C basic helix-loop-helix protein 13 antibody; FLJ35523 antibody; Likely ortholog of mouse Max dimerization protein 3 antibody; MAD3_HUMAN antibody; MAX dimerization protein 3 antibody; Max dimerizer 3 antibody; Max-associated protein 3 antibody; Max-interacting transcriptional repressor MAD3 antibody; MGC2383 antibody; mxd3 antibody; Myx antibody; OTTHUMP00000223596 antibody; OTTHUMP00000223598 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Max dimerization protein 3 protein (1-206AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.
Gene References into Functions
  1. results indicate that MXD3 is a potential new target and that the use of MXD3 siRNA nanocomplexes is a novel therapeutic approach for neuroblastoma PMID: 28419087
  2. The results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor. PMID: 25554682
  3. Acute MXD3 activation results in a transient increase in DAOY cell proliferation while persistent activation of MXD3 results in an overall decrease in cell number, suggesting that the time course of MXD3 expression dictates the cellular outcome. PMID: 25053245
  4. Increased level and/or duration of MXD3 expression ultimately reduces cell numbers via increased cell death and cell cycle arrest in medulloblastoma cells. PMID: 22808009
Subcellular Location
Nucleus.
Database Links

HGNC: 14008

OMIM: 609450

KEGG: hsa:83463

STRING: 9606.ENSP00000401867

UniGene: Hs.743332

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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